KEYNOTE-A18 Final OS Data and Patient Selection

This Medudy course is a video tutorial for physicians on current treatment options for locally advanced cervical cancer.

In this video, Prof. Dr. Annette Hasenburg, Director of the Department of Obstetrics and Women’s Health at Mainz University Medical Center, presents the final survival data from the KEYNOTE-A18 study and assesses the role of pembrolizumab in combination with chemoradiotherapy. The focus is on the final data presented at ASCO 2025 for patients with FIGO 2014 stage III to IVA.

In addition, Prof. Hasenburg explains how patients are selected for therapy and addresses an important challenge in everyday clinical practice: While approval is based on the 2014 FIGO classification, the 2018 FIGO classification is used today. Drawing on the differences between the two classifications, he explains in particular how patients are classified as Stage IIIC according to the 2018 FIGO classification.

Note: All “speakers” appearing in Medudy videos are AI-based avatars used to enhance the educational value of the videos. The individuals on whom the avatars are based have explicitly consented to their use. All content is based on high-quality scientific sources and is created and reviewed by the Medudy team of doctors.

This course was made possible with the generous support of MSD.

At the end of this training you will know:

  • the final survival data from the KEYNOTE-A18 study
  • The Role of Pembrolizumab in Combination with Radiochemotherapy in Locally Advanced Cervical Cancer
  • The practical application of the FIGO 2014 and FIGO 2018 classifications for patient selection

Further courses