This Medudy course is a video tutorial for physicians on the topic of "Acute pain therapy using NaV1.8 inhibition". The format used here is a so-called "Journal Club Summary", in which we summarize the latest and most clinically relevant studies for you.
Acute pain is a major clinical challenge and is often treated with opioids, despite the risk of abuse and dependence. The voltage-gated sodium channel NaV1.8 represents a promising therapeutic target for pain treatment, as it plays a crucial role in the transmission of nociceptive signals and is selectively present in peripheral nociceptive neurons of the dorsal root ganglia. Today's two phase 2 clinical trials are therefore analyzing the efficacy and safety of VX-548 - an oral, highly selective NaV1.8 inhibitor - in patients with acute postoperative pain following abdominoplasty or bunionectomy.
Note: All "speakers" appearing in the Medudy videos are AI-based avatars used to improve the didactics of the videos. The people on whom the avatars are based have explicitly consented to their use. All content is based on high-quality scientific sources and is created and reviewed by the Medudy medical team.
At the end of this course you will know
- the clinical background and relevance of the research question under investigation
- the study design and methodology of the publication to answer the research question
- the results and key takeaways of the publication
- the conclusion of the publication and possible limitations
